You wanted it, we gave it... best of ASCO ...colon...2025 :D

In this episode, hosts James and Sapna discuss the key highlights from ASCO 2025, focusing on significant abstracts related to melanoma treatment. They delve into the implications of adrenal insufficiency, the 5 year, final results of Lifileucel, and the ongoing debate between neoadjuvant and adjuvant therapies. The conversation also explores the role of IL-6 in treatment efficacy and the importance of understanding sentinel lymph node positivity. The hosts emphasize the need for innovative clinical trial designs to adapt to emerging data and improve patient outcomes.

Keywords

ASCO 2025, melanoma, neoadjuvant therapy, adrenal insufficiency, lifileucel, immunotherapy, clinical trials, IL-6, treatment outcomes, cancer research

Chapters

00:00 Introduction and Overview of ASCO 2025

03:16 DoorDash!

05:43 Key Highlights from ASCO 2025

08:29 Lifileucel and Its Impact on Treatment

10:53 Long-term Outcomes and Toxicity Considerations

15:49 Exploring Treatment Efficacy in Refractory Populations

17:41 Neoadjuvant and Adjuvant Therapies: A Comparative Analysis

21:07 Investigating GM-CSF's Role in Mitigating Toxicity

22:36 RELA 098: Insights and Implications

25:37 Understanding Sentinel Lymph Node Positivity in Melanoma

26:34 Future Directions in Neoadjuvant Therapy Research

36:18 Fact Check

38:17 Discussion on IPI GM-CSF and Adrenal Insufficiency

42:09 Impact of Adrenal Insufficiency on Patients

45:06 Future Directions in Neoadjuvant Trials

47:26 Wrap-Up and Reflections