Acute Coronary Syndrome (ACS) remains a leading cause of morbidity and mortality worldwide, demanding a nuanced approach to diagnosis, risk stratification, and management. In this episode of MedPOD AFMC, host Brig (Dr) J Muthukrishnan is joined by Lt Col (Dr) Ankush Gupta, an eminent cardiologist from the Army Institute of Cardio-Thoracic Sciences, to discuss the evolving landscape of ACS care.From recognizing different clinical presentations to utilizing high-sensitivity biomarkers and risk scores, this conversation delves into the latest advancements in ACS assessment. The discussion also explores modern treatment strategies. With an evidence-based approach and real-world insights, this episode provides a comprehensive understanding of ACS, making it an essential listen for physicians, medical students, and healthcare professionals involved in acute cardiac care.