This weekend's CFB Week 10 clash between the Iowa State Cyclones and the Arizona State Sun Devils is far more than a mid-season college football contest; it's a volatile Big 12 Championship rematch. Though both programs, currently sitting at 5-3, are likely outside the College Football Playoff picture and the immediate Big 12 standings race, the historical bad blood and high stakes for bowl eligibility make this a massive game. Last year’s title bout, which saw the Sun Devils claim the trophy, ensures the atmosphere at Jack Trice Stadium will be electric, providing must-watch NCAA football content for fans and YouTube highlight creators. The central storyline is navigating significant injury news. Iowa State is fighting through deep secondary woes and running back rotation issues, while Arizona State’s offense is reeling from the loss of starting quarterback Sam Leavitt and the questionable status of top wide receiver Jordyn Tyson, forcing veteran Jeff Sims into the starting role. This defensive and offensive attrition changes the entire game day preview and prediction landscape. Look for a hard-fought, smashmouth football game characterized by strong defensive play. The key to victory will be who manages the debilitating injury crisis better. Despite falling short of preseason expectations, this Big 12 matchup is crucial for 2025 recruiting momentum and provides a critical test of character for both head coaches