This episode does a deep dive into a two-year, randomized-controlled trial, investigating the effect of menopausal hormone therapy (MHT) on bone mineral density (BMD) in postmenopausal women. The study compared different dosages of conjugated equine estrogen (CEE) combined with either micronized progesterone (MP) or dydrogesterone (DHG) across three groups. Researchers measured changes in lumbar and hip BMD, along with bone metabolism biomarkers like ALP, Ca, P, Cr, and Ca/Cr, to evaluate treatment effectiveness and safety.
Zuo H, Sun A, Gao L, et al. Effect of Menopausal Hormone Therapy on Bone Mineral Density in Chinese Women: A 2-Year, Prospective, Open-Label, Randomized-Controlled Trial. Med Sci Monit. 2019;25:819-826. Published 2019 Jan 28. doi:10.12659/MSM.912166
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