In this episode examine the key concepts of chemical synthesis, structural determination, and biological function, through the work of R.B. Woodward, who approached organic synthesis as an art form, Dorothy Hodgkin, who used X-ray diffraction to make molecular structures \"real\" , and Venkatraman Ramakrishnan, whose work on the ribosome revealed how RNA senses base-pairing geometry and ensures fidelity. This episode will explore the tools, challenges, and breakthroughs in these scientific fields. Disclaimer: This podcast is for educational purposes. While every effort has been made to ensure accuracy, the producers are not responsible for errors or omissions. Listeners should seek advice from qualified professionals when necessary.