Michael McGuire shares his remarkable journey in dentistry and periodontology in an inspiring conversation with Pamela K. McClain on the Legends of Oral Regeneration podcast. From his early passion for surgery and science to becoming a leader in oral regeneration, McGuire's story is one of big dreams that have come true. Discover how he transformed his private practice into a hub for innovation, founding iMc - a network of investigators advancing practice-based research. McGuire emphasises the importance of real-world evidence in advancing dental care. He illustrates how long-term studies and patient-reported outcomes are bridging the gap between research and clinical practice.  Reflecting on his early struggles as a young researcher, McGuire highlights the importance of perseverance and mentorship. This episode is a must-listen for anyone passionate about oral tissue regeneration.