In this episode of the YPO Leader of Leaders podcast, Diana Daniels sits down with Rami Elghandour—engineer, investor, and YPO Global member who grew Nevro into a $3B company and now leads Arcellx—to talk about what it really takes to build a company that lasts. They dive into why alignment between vision and execution is so often missing, how leaders can build cultures that encourage innovation and risk-taking, and why diversity in leadership isn’t just a nice-to-have—it’s a real competitive edge. Rami shares honest insights on hiring for potential, connecting people to purpose, and building companies that don’t just succeed, but make a lasting impact.
Here are the things that we talked about:
Leaders need to align purpose, people, and performance to build lasting impact.
Creating space for risk and failure is key to driving meaningful innovation.
Hiring for potential—not just experience—can unlock exceptional talent.
Recognition and visibility help employees connect their work to the bigger mission.
Diverse leadership isn’t a checkbox—it’s a competitive advantage.
A strong sense of purpose fuels engagement, resilience, and growth.
CEOs and boards play a critical role in shaping inclusive, high-performing cultures.
Tools like town halls, diverse candidate slates, and clear communication help build alignment.
Learn more about Rami Elghandour:LinkedIn: https://www.linkedin.com/in/ramielghandour
Website: https://ramielghandour.com
Website: https://www.arcellx.com
Learn more about Diana Daniels:LinkedIn: https://www.linkedin.com/in/dianadaniels/Website: https://cronosgroup.net/