Migraines are a debilitating neurological condition characterised by severe, recurring headaches, often accompanied by symptoms such as nausea, vomiting, and sensitivity to light and sound. Despite the availability of various pharmacological treatments, the search for effective, well-tolerated, and safe preventive measures remains a priority. Among the various non-pharmacological interventions, vitamin B2 (riboflavin) has emerged as a promising candidate. This podcast explores the potential of vitamin B2 in the management of migraines, examining the underlying mechanisms, clinical evidence, and practical considerations for its use.