Cancer treatment has entered a transformative era in 2025, characterised by remarkable advances in immunotherapy, personalised medicine, and artificial intelligence integration. Significant developments include personalised cancer vaccines targeting unique mutations, advanced radiotherapy techniques, and targeted therapies for previously “undruggable” cancers. Artificial intelligence has emerged as a pivotal force, revolutionising drug discovery, diagnostic accuracy, and treatment planning across the United Kingdom and globally. This podcast and free PDF briefing document report examines the most significant breakthroughs reshaping oncological care, with particular emphasis on AI’s expanding role in research and clinical practice.