This article provides a comprehensive review of extraction and determination techniques for acrylamide (AA) in food matrices, focusing on innovative and sustainable methods. It analyzes the advantages and disadvantages of traditional methods, such as dispersive liquid-liquid microextraction (DLLME), QuEChERS, and solid-phase extraction (SPE), and introduces more efficient alternatives, including accelerated solvent extraction (ASE), headspace solid-phase microextraction (HS-SPME), and the use of supramolecular solvents and ionic liquids. Additionally, innovative detection techniques are discussed, such as supercritical fluid chromatography with tandem mass spectrometry (SFC/MS/MS), surface-enhanced Raman spectroscopy (SERS), and fluorescence spectroscopy. Finally, ideal methods for AA extraction from different food matrices are proposed, with a focus on sustainability and reducing the use of organic solvents. DOI: https://doi.org/10.1016/j.trac.2023.117267

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