Drs. Sahil Parikh, Robert Attaran, Pamela Kim, and Jeff Carr discuss the newly released SCAI guidelines on chronic venous disease (CVD), highlighting key takeaways from the comprehensive review. They discuss the clinical rationale behind the evidence-based recommendations, including guidance on compression therapy, vein ablation, and revascularization strategies. The panel also explores the decision-making algorithms developed to streamline treatment and areas where further research is urgently needed.Read the JSCAI article: https://doi.org/10.1016/j.jscai.2025.103729