In this episode of the Journal of Neurophysiology's podcast series, we spotlight the research titled “Discovery of the Aβ receptor that controls the voltage-gated sodium channel activity: unraveling mechanisms underlying neuronal hyperexcitability.” Alzheimer’s disease is well known for memory loss and cognitive decline—but behind these symptoms lies a web of complex neuronal dysfunction. This study reveals that amyloid beta peptides (Aβs), known to enhance sodium channel activity and drive hyperexcitability, exert their effects via an unexpected molecular player: the type I taste receptor, T1R2/T1R3. Using advanced patch-clamp techniques, the researchers identified this novel Aβ receptor, opening a promising new path for therapeutic intervention. By targeting this receptor, future treatments may be able to reduce Aβ-induced hyperactivity and slow AD progression.   Discovery of the Aβ receptor that controls the voltage-gated sodium channel activity: unraveling mechanisms underlying neuronal hyperexcitability Mitsuyoshi Luke Saito, Tsutomu Sasaki, and Mariko Ruth Saito Journal of Neurophysiology 2025 133:6, 1861-1885