In this episode of the Journal of Neurophysiology’s podcast series, coauthor Andrea Gigliotti discusses the newly published review, “Emerging evidence on the effects of electrode arrangements and other parameters on the application of transcutaneous spinal direct current stimulation.” Gigliotti explains how computer simulations are helping researchers understand the role of electrode placement, polarity, and tissue properties in shaping tsDCS outcomes. He also describes why dosage may matter less than previously thought and what future trials should consider to make tsDCS more effective in both research and clinical settings.   Emerging evidence on the effects of electrode arrangements and other parameters on the application of transcutaneous spinal direct current stimulation Andrea Gigliotti and Hugo M. Pereira Journal of Neurophysiology 2025 133:2, 709-721