This episode of the Journal of Gynecologic Oncology podcast explores a post hoc analysis of the Japanese Gynecologic Oncology Group 2043 study, led by Yosuke Konno in Japan. The study evaluated the prognostic significance of para-aortic lymphadenectomy and para-aortic lymph node metastasis in high-risk endometrial cancer. Findings showed that para-aortic lymphadenectomy did not independently improve survival, but multiple para-aortic metastases were associated with significantly worse outcomes, likely indicating systemic disease. In contrast, patients with a single positive para-aortic lymph node had similar survival rates to those without metastases. These results highlight the need for individualized treatment strategies, including the potential role of immunotherapy. Tune in for a detailed discussion of the findings and their clinical implications.

Prognostic significance of para-aortic node metastasis in endometrial cancer: Japanese Gynecologic Oncology Group Study JGOG2043 Post hoc analysis (https://doi.org/10.3802/jgo.2025.36.e57)