In this episode of the Journal of Gynecologic Oncology podcast, we discuss a study by Kanno and colleagues examining the impact of cytoreductive surgery on outcomes in high tumor burden ovarian cancer following the introduction of poly ADP-ribose polymerase inhibitors. This retrospective analysis of 434 patients found that, while complete cytoreduction remains essential, the use of poly ADP-ribose polymerase inhibitors may improve progression-free survival for patients with extensive tumor burden. However, higher surgical complexity was associated with increased complication rates. These findings highlight the evolving role of maintenance therapy and the importance of optimizing surgical approaches to enhance patient outcomes. Tune in to learn more about the implications for clinical practice in the poly ADP-ribose polymerase inhibitor era.

The Impact of Cytoreductive Surgery on outcomes in High Tumor Burden Ovarian Cancer after induction of PARP inhibitors