In this episode, Editor-in-Chief Marcelo F. Di Carli, MD, MASNC, is joined by Waseem Hijazi, MD and Robert JH Miller, MD, FASNC from the University of Calgary to discuss their manuscript 'Association of medical therapies with survival according to SPECT MPI findings'. The study shows that integrating coronary artery calcium scoring with SPECT MPI improves risk stratification and guides more effective medical therapy in patients with suspected CAD. Their findings suggest that hybrid imaging can meaningfully influence clinical outcomes by identifying patients most likely to benefit from statins and ACE/ARB therapy. The discussion highlights a shift toward using nuclear cardiology not just for diagnosis, but to personalize and optimize care.