In this episode, we discuss novel approaches for the treatment of major depression and anxiety.
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We discuss
0:00:00- Introduction
0:03:51- The biology of depression and proposed mechanisms, purpose and meaning, the comfort crisis, the hedonic treadmill, societal changes
0:19:35- The domains of happiness, countries where people tend to be the happiest, discussion of "Man's search for meaning" by holocaust survivor Viktor Frankl, dopamine and the reward pathway
0:23:55- The loneliness epidemic, letting go of the 'ego', protective factors preventing depression
0:26:45- Inflammation and depression, omega-3 fatty acids, creatine, exercise, ketogenic diets, transcranial magnetic stimulation
0:36:35- Diagnosis of depression, SSRIs and their limitations
0:51:30- Anxiety, associative awareness technique, exercise, stoicism, deep breathing techniques
1:09:19- The history of psychedelics and how they affect the brain (default mode network), psilocybin study, ketamine, MDMA, stigmatization, the future of psychedelics
STUDIES
Bosch, O.G., Halm, S. & Seifritz, E. Psychedelics in the treatment of unipolar and bipolar depression. Int J Bipolar Disord 10, 18 (2022). https://doi.org/10.1186/s40345-022-00265-5
Julian G Martins (2009) EPA but Not DHA Appears To Be Responsible for the Efficacy of Omega-3 Long Chain Polyunsaturated Fatty Acid Supplementation in Depression: Evidence from a Meta-Analysis of Randomized Controlled Trials, Journal of the American College of Nutrition, 28:5, 525-542, DOI: 10.1080/07315724.2009.10719785
Kious BM, Kondo DG, Renshaw PF. Creatine for the Treatment of Depression. Biomolecules. 2019; 9(9):406. https://doi.org/10.3390/biom9090406
Davis AK, Barrett FS, May DG, et al. Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2021;78(5):481–489. doi:10.1001/jamapsychiatry.2020.3285
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC486942/ https://journals.sagepub.com/doi/epub/10.1177/02698811211073759 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181681/