Today, my guest is Dr. Matt Kaeberlein, a CEO of Optispan, anti-aging researcher, Professor at the University of Washington, and founding Director of the University of Washington Healthy Aging and Longevity Research Institute. Dr Kaeberlein is the author of over 250 published scientific research articles on aging, healthspan, and longevity of people and companion animals. Dr. Kaeberlein is a Fellow of the American Association for the Advancement of Science, the American Aging Association, and the Gerontological Society of America. He has received numerous prestigious awards from organizations such as the Alzheimer’s Association and the National Institutes of Health. He has co-founded two companies, Ora Biomedical, Inc., a leading longevity drug discovery biotech, and Optispan, Inc., a healthcare technology company focused on developing innovative tools for 21st-century medicine. He is also the Co-Founder of the Dog Aging Project and Dog Aging Institute. In this episode, Dr Kaeberlein explains the science and practice of nutrition and longevity. We cover animal and human research on nutrition and anti aging. We discuss calorie restriction, intermittent fasting, time-restricted eating, keto diet (ketogenic diet), protein, Mediterranean diet, and the carnivore diet. We also discuss mechanisms of aging and the most convincing human evidence for nutrition and longevity. Finally, Dr Kaeberlein gives tips and tools for everyday anti aging. We also discuss anti aging in dogs (Dog Aging Project). ------------------------------------------------------ SUBSCRIBE TO Spotify: https://shorturl.at/wAKM2 iTunes: https://podcasts.apple.com/ee/podcast/inka-land-podcast/id1654391974 ------------------------------------------------------ SIGN UP / FOLLOW Newsletter: https://www.inkaland.co/newsletter Instagram: https://www.instagram.com/iaminkaland/ Subscribe: https://www.youtube.com/@iaminkaland?sub_confirmation=1 ------------------------------------------------------ DR MATT KAEBERLEIN LINKS Website: https://www.optispan.life/ YouTube: https://www.youtube.com/@optispan X: https://x.com/mkaeberlein Dog Aging Project: https://dogagingproject.org/ ------------------------------------------------------ DISCLAIMER https://www.inkaland.co/disclaimer ------------------------------------------------------ TIMESTAMPS 00:00 Intro 00:00:25 Anti Aging Trends 00:04:00 Anti aging, longevity, and healthspan 00:11:50 Healthspan and Biology of Aging 00:13:27 Healthspan and Biology of Aging 00:14:35 Health in Organs 00:15:50 NAD, Health Decline, and Optimal Age for Anti aging 00:17:40 Reversing Aging Damage 00:19:20 Anti Aging Nutrition Research 00:21:10 Caloric Restriction, Calorie Restriction, and Protein Restriction 00:26:00 Risks of Extrapolating and Inflammation 00:28:30 Caloric Restriction, Reproduction and Hormonal Health 00:32:00 Can Ketogenic Diet Increase Lifespan 00:32:50 Genes, Keto diet and Health Benefits 00:35:20 Tool: Blood Test, Labs, DEXA, Vo2max, etc 00:37:15 Biological Age Tests 00:38:20 Human Nutritional Strategies for Anti Aging (Anti Aging diet) 00:39:00 Non-Diet Factors 00:39:40 Sugar, Protein, Continuous Glucose Monitoring, Processed Foods 00:41:20 Mediterranean Diet, MIND Diet, Alzheimer’s Disease 00:42:45 Alcohol 00:43:21 Extreme Diet and Carnivore Diet 00:44:45 Inflammation, Food Intolerance, Immunity, Allergy and Aging 00:50:00 Biological Mechanisms of Aging 00:53:00 IGF-1, mTOR, and cancer 00:54:40 mTOR and Rapamycin, FGF21 00:58:30 Dr. Matt Kaeberlein Longevity Protocol 01:04:00 Anti Aging in Dogs: Dog Aging Project