Today, my guest is Ryan Smith, a biotech innovator, epigenetics expert, and founder of TruDiagnostic, one of the world’s most advanced labs for biological age testing, DNA methylation analysis, and epigenetic clocks.
He previously founded Tailor Made Compounding, a peptide pharmacy that became fastest-growing healthcare company in the U.S., generating $80 million in revenue in just three years.In this episode, Ryan breaks down the science of anti-aging and longevity peptides, including Tesamorelin, Ipamorelin, SS-31, MOTS-c, Os-01, thymosin alpha-1, and ATX-304—covering how they work, when to use them, and their roles in mitochondrial health, fat loss, muscle growth, immune modulation, and biological rejuvenation.We also discuss FDA regulations around peptides and how peptides compare to pharmaceuticals and lifestyle interventions. We also cover hair growth and skin anti-aging peptides and how to use them.In the second part of the episode, we cover biological age testing (epigenetic age testing), including DunedinPACE, PhenoAge, and telomere length. Finally, Ryan shares his personal peptide protocols for longevity.FREE GUIDEDownload a free supplement guide: https://inkaland.co/supplement-guide------------------------------------------------------
RYAN SMITH & TRUDIAGNOSTICWebsite: trudiagnostic.comLinkedIn: Ryan SmithYouTube: TruDiagnostic ChannelX (formerly Twitter): @TruDiagnostic------------------------------------------------------DISCLAIMERhttps://www.inkaland.co/disclaimer------------------------------------------------------TIMESTAMPSPART 1: ANTI-AGING AND LONGEVITY PEPTIDES00:00 Introduction00:12 Ryan Smith introduction: TruDiagnostic, Tailor Made Peptides03:00 Ryan’s story: Medical school, peptides, and preventive health04:15 What are peptides and how are peptides made?06:50 FDA peptides - are peptides legal?06:50 Peptide vs pharmaceuticals08:50 FDA peptides for anti-aging and prevention10:30 Collagen peptides vs therapeutic peptides12:40 Anti-aging and longevity peptides12:52 SS31: mechanism, mitochondria, and ss-31 uses13:30 Mitochondria peptides, ss-31 continued14:15 Mots-c review17:40 SS31 dosage18:15 Peptides vs small molecules19:20 Anti-aging peptide: Os-01 ATX304 M-kinase, AMPK19:50 AMPK: the longevity anti-aging pathway21:18 ATX304 AMPK-mimetics22:15 ATX304 vs rapamycin vs Berberine vs Metformin24:00 Os-01 vs calorie restriction vs fasting25:50 Peptides vs lifestyle28:40 Peptides for weight loss: Tesamorelin, ipamorelin, cjc 1295, Ozempic, Growth hormone peptides29:20 Growth hormone peptides, igf-131:20 Fat loss peptides: ipamorelin, tesamorelin, glp-1 agonist, ozempic31:20 Peptides for visceral fast32:50 Growth hormone peptides review vs longevity34:18 Glp 1 receptor agonist mechanism of action: Ozempic, semaglutide, etc36:10 Immunity peptides: thymosin alpha 1 benefits37:55 Thymusin beta 4 vs tymosin alpha 138:50 Antimicrobial peptides39:25 Thymusin beta 4 and BPC157 review40:50 sglt2 inhibitors41:40 Peptide protocols: daily use vs cycling42:40 Hair growth peptides43:40 Hair growth peptide: PDT-DBM44:30 Hair growth peptide: GH-CKu copper peptide and thymulin46:50 Copper peptide for face and hair protocol47:35 Ryan Smith peptide protocolPART 2: BIOLOGICAL AGE AND PACE OF AGING48:40 Biological age vs chronological age vs speed of aging51:50 Biological age test: omic age clock, Dunedinpace, Symphony Age52:20 Improving metabolic age, cardiovascular age, and kidney age54:22 Hyberbaric Oxygen: brain health and cardiovascular health54:40 Semaglutide glp 1 receptor agonist and longevity56:30 Dunedinpace test, speed of aging57:58 How does Ryan slow down biological age and speed of aging?59:00 Ryan Smith links, TruDiagnostic
