In late May 1806, three of Richmond’s best doctors rushed to the home of George Wythe—a prominent judge, signer of the Declaration of Independence, and Thomas Jefferson’s long-time mentor and dear friend. The physicians discovered Wythe bedridden, in agonizing pain. The cause? Poison. The likely culprit? Wythe’s own nephew. In this latest episode of our “In the Course of Human Events” podcast, Monticello Guide David Thorson—with help from colleagues Melanie Bowyer and Carrie Soubra—shares this harrowing tale of debt, greed, racism, and death.