This episode examines the critical intersection of NHS data infrastructure and life sciences innovation through the lens of a recent ABPI report. The assessment, conducted in collaboration with key trade associations, evaluates the readiness of the NHS Secure Data Environment (SDE) network to support commercial research activities. Drawing from extensive industry consultation, the report identifies significant challenges facing pharmaceutical and medical technology companies seeking to leverage NHS data, including access limitations, technical capability gaps, and governance hurdles. The discussion explores how these barriers impact the UK’s competitive position in global life sciences and outlines strategic recommendations for enhancing the SDE network’s effectiveness. Particular attention is given to the need for standardized data access protocols, improved technical infrastructure, and streamlined governance frameworks that balance security with usability. The episode highlights the transformative potential of properly harnessed NHS data resources for advancing medical innovation and improving patient outcomes across Britain. By examining both industry concerns and proposed solutions, this conversation provides valuable insights into how stakeholders can collaborate to strengthen the UK’s data environment and accelerate life sciences research through more effective utilization of the NHS’s vast data resources.