Did you know that urban planners inadvertently created allergy hotspots by favoring male trees in city landscapes? This episode of ImmunoCAST takes listeners on a cross-country journey, exploring how allergies manifest differently across various US regions. We address the challenge of identifying and managing region-specific allergens, from urban environments to coastal areas and the heartland. Topics covered include the impact of imported fire ants in the Southeast, the prevalence of dust mites in humid climates, and the surprising connection between birch trees and peanut allergies in the Northeast. We also delve into the emerging concern of cannabis allergies in the Midwest and the unique "cedar fever" phenomenon in the Southwest. The episode concludes with practical insights on diagnostic approaches and the importance of considering both allergic and non-allergic triggers in patient evaluations.Episode references and resources available here:https://www.thermofisher.com/phadia/us/en/resources/immunocast/allergy-triggers-treatments-across-america.html