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Hope Lies in Dreams
Nature Biotechnology
11 episodes
7 months ago
Stan Crooke rose from poverty to found a company that pioneered antisense drugs. After decades of struggle and years of public doubt, the company created a treatment that has saved thousands of children from the brutal disease spinal muscular atrophy.

Hosted on Acast. See acast.com/privacy for more information.

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Entrepreneurship
Business,
Health & Fitness,
Medicine,
Science,
Life Sciences
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All content for Hope Lies in Dreams is the property of Nature Biotechnology and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
Stan Crooke rose from poverty to found a company that pioneered antisense drugs. After decades of struggle and years of public doubt, the company created a treatment that has saved thousands of children from the brutal disease spinal muscular atrophy.

Hosted on Acast. See acast.com/privacy for more information.

Show more...
Entrepreneurship
Business,
Health & Fitness,
Medicine,
Science,
Life Sciences
Episodes (11/11)
Hope Lies in Dreams
Chapter 10: Dr. Crooke
The biggest deal ⬩ In the black ⬩ End of an era ⬩ n of 1 ⬩ Small places ⬩ A life of control ⬩ The doctor will see you now

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4 years ago
50 minutes 53 seconds

Hope Lies in Dreams
Chapter 9: the last of his kind
Award season ⬩ NURTURE, and Gabriel ⬩ Kyle Derkowski’s new future ⬩ The drugs of SMA ⬩ Piece of magic ⬩ Frank’s Super Bowl

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4 years ago
39 minutes 9 seconds

Hope Lies in Dreams
Chapter 8: part of something big
Ethics lessons ⬩ Biogen re-ups ⬩ The ultimate sacrifice ⬩ FDA as partner ⬩ Emma’s phase 3 ⬩ Doug Kerr’s bright idea ⬩ Isis to Ionis ⬩ Spinraza approval

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4 years ago
42 minutes 23 seconds

Hope Lies in Dreams
Chapter 7: the SMA gang
The Larsons ⬩ The skunkworks project ⬩ The most unmet need ⬩ Instant synergy ⬩ Another first for antisense ⬩ The clinic, again ⬩ The achievements of Kathie Bishop

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4 years ago
40 minutes 23 seconds

Hope Lies in Dreams
Chapter 6: lone voice in the wilderness
Rosanne saves the company ⬩ Ibis is sold ⬩ An approval ⬩ Souring on Genzyme ⬩ The end of Genta ⬩ The discovery of the SMA gene

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4 years ago
43 minutes 12 seconds

Hope Lies in Dreams
Chapter 5: valley of antisense
The genomics bubble ⬩ Affinitak fails ⬩ Lynne saves the company ⬩ Hybridon pivots ⬩ New chemistries ⬩ Regulus formed ⬩ Isis as cult

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4 years ago
41 minutes 37 seconds

Hope Lies in Dreams
Chapter 4: three kinds of failure
Stumbling out of the gate ⬩ Launch of Vitravene ⬩ Questions about antisense ⬩ The field thins ⬩ Clinical failure ⬩ The darkest days

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4 years ago
43 minutes 47 seconds

Hope Lies in Dreams
Chapter 3: San Diego restart
Rosanne ⬩ An investor emerges ⬩ Founding Isis ⬩ The old garage ⬩ A proper space ⬩ A growing antisense scene ⬩ Starting a pipeline ⬩ Isis goes public

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4 years ago
47 minutes 35 seconds

Hope Lies in Dreams
Chapter 2: a winding path
Quits Purdue ⬩ Pharmacy school ⬩ Off to Baylor ⬩ Harris Busch ⬩ Bristol Labs ⬩ SmithKline ⬩ The death of Nancy Crooke ⬩ The end of SmithKline

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4 years ago
46 minutes 37 seconds

Hope Lies in Dreams
Chapter 1: an ugly place
Stan Crooke is born ⬩ A tenuous existence ⬩ Life with his mother ⬩ The Tech Corner ⬩ Arsenal Tech High School ⬩ Nancy ⬩ Hoodlum ways ⬩ Off to Purdue

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4 years ago
32 minutes 2 seconds

Hope Lies in Dreams
Hope Lies in Dreams trailer
Trailer for upcoming 10-part series, Hope Lies in Dreams.

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4 years ago
2 minutes 22 seconds

Hope Lies in Dreams
Stan Crooke rose from poverty to found a company that pioneered antisense drugs. After decades of struggle and years of public doubt, the company created a treatment that has saved thousands of children from the brutal disease spinal muscular atrophy.

Hosted on Acast. See acast.com/privacy for more information.