Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

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Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Joanne Kennedy

25 episodes

12 hours ago

Can histamine be the hidden reason behind your anxiety? In this episode, I break down how histamine acts as a neurotransmitter in the brain — and why an overload can leave you wired, anxious, and unable to relax. We dive into how methylation, estrogen, mold, and gut inflammation (including SIBO and oxalates) all feed into the histamine-anxiety loop. Whether you're a practitioner treating patients with anxiety or someone who’s tried everything to feel better — this episode gives you a deeper...

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Alternative Health

Health & Fitness,

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Can histamine be the hidden reason behind your anxiety? In this episode, I break down how histamine acts as a neurotransmitter in the brain — and why an overload can leave you wired, anxious, and unable to relax. We dive into how methylation, estrogen, mold, and gut inflammation (including SIBO and oxalates) all feed into the histamine-anxiety loop. Whether you're a practitioner treating patients with anxiety or someone who’s tried everything to feel better — this episode gives you a deeper...

Show more...

Alternative Health

Health & Fitness,

Episodes (20/25)

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

20. Acid Load, Mineral Depletion & the Hidden Link to Histamine Intolerance & Oxalates

In this episode of The Histamine Well, we're diving into one of the most overlooked root causes behind symptoms like fatigue, histamine intolerance, hormonal imbalance, oxalate sensitivity, mood swings, and chronic inflammation: acid load and mineral depletion. You'll learn: Where acidity in the body comes from — from diet and inflammation to mitochondrial dysfunction and gut dysbiosisHow acid load disrupts key systems, including hormones, energy, detoxification, and neurotransmittersWhy hist...

5 days ago

33 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

19. Clinical Insights into PMDD, Severe PMS & the Role of Methylation

In this episode of The Histamine Well, Joanne dives deep into Premenstrual Dysphoric Disorder (PMDD) and severe PMS — the kind that can leave you feeling anxious, depressed, exhausted, and unlike yourself for half the month. Joanne shares insights from her clinical practice to explore what’s really going on beneath the surface, including: Hormone imbalances like estrogen dominance and low progesteroneInflammation, oxidative stress, and their impact on ovulationNutrient deficiencies that affec...

1 week ago

15 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

18. Balancing Methylation: A Game-Changer for Mental Health, Perimenopause & Menopause

In this episode of The Histamine Well, host Joanne speaks with Amanda Bradshaw, co-founder of Mood Sense, to explore the critical role methylation plays in mood, mental health, and hormonal transitions like perimenopause. Joanne shares her clinical insights and surprising test results showing that some patients assumed to be under-methylators were actually over-methylating—changing the course of their treatment. Amanda opens up about her personal health journey through perimenopause and how b...

2 weeks ago

1 hour

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

17. How Gluten Causes Immune Dysfunction, Chronic Inflammation and High Histamine

In this episode, Joanne Kennedy discusses a comprehensive case study of a patient with various symptoms like abdominal pain, migraines, and joint pain who was incorrectly suspected of having mold and oxalate problems. The root cause turned out to be gluten intolerance. Joanne explains the impact of gluten on the immune system, highlighting how it can cause significant inflammation and histamine issues. She differentiates between celiac disease, wheat allergy, and non-celiac gluten sensi...

3 weeks ago

24 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

16. Emotional Eating, Gut Health & Histamine: A Conversation with Amber Romaniuk

In this episode of the Histamine Well Podcast, Joanne is joined by Amber Romanic, an expert in emotional eating, digestion, and hormonal health. Amber shares her personal journey overcoming emotional eating and discusses how it impacts gut health and increases histamine levels. They explore common emotional eating triggers, the role of high cortisol, and the pitfalls of extreme diets like intermittent fasting. Amber offers practical tips on managing emotional eating, the importance of healing...

1 month ago

44 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

15. The Connection Between High Histamine Levels and Hypoglycemia

In this episode of the Histamine Well Podcast, Joanne explores the surprising link between high histamine levels and hypoglycemia. She details how elevated histamine can disrupt blood sugar regulation through various mechanisms, including overstimulation of insulin production, suppression of glucagon, and cortisol dysregulation. Joanne also offers practical advice on managing high histamine and blood sugar levels through diet, stress management, and lifestyle changes. Tune i...

1 month ago

13 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

14. Understanding SIBO and Histamine: An In-Depth Discussion with Joanne Kennedy & Melanie Peers

In this episode of the Histamine Well Podcast, Joanne is joined by her colleague Melanie Peers to discuss the relationship between small intestinal bacterial overgrowth (SIBO) and histamine intolerance. They explore the complexities of SIBO, its causes, symptoms, and its impact on histamine levels in the body. Joanne and Melanie also delve into related issues such as the role of the migrating motor complex, the influence of stress, dietary impacts, and the significance of mold, oxalates...

1 month ago

1 hour

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

13. The Role of Digestive Enzymes in Gut Health and Histamine Balance

In this episode of the Histamine Well Podcast, host Joanne Kennedy delves into the significance of digestive enzyme deficiencies in managing histamine intolerance and chronic gut issues like SIBO. Joanne explains the critical roles of hydrochloric acid, pancreatic enzymes, and bile acids in maintaining a healthy digestive system, and how their insufficiencies can lead to increased histamine levels and poor gut health. The episode covers the symptoms, causes, and solutions for enzy...

1 month ago

24 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

12. The Connection between Methylation, Gallbladder Health & Histamine with Nutritionist Olivia Hass

In this episode of the Histamine Well podcast, Joanne dives into the connection between methylation, detoxification, and gallbladder health. Joined by nutritionist Olivia Haas, they discuss how impaired methylation affects bile flow, leading to gallbladder dysfunction and increased histamines. Olivia explains the essential role of the gallbladder in digestion, detoxification, and overall health. They cover early warning signs of gallbladder issues, appropriate testing, and the interplay...

2 months ago

47 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

11. Practical Tips for Lowering Histamine Levels Quickly

In this episode of the Histamine Well Podcast, Joanne does something a little different. She shares her step-by-step approach for rapidly lowering your histamine bucket while working toward identifying and treating the root cause. This episode is packed with clinical gems and practical strategies—perfect for both patients and practitioners. In this episode, you’ll learn: Why a low histamine diet is your first line of defense—and where to find a reliable food listHow DAO enzymes like Seeking H...

2 months ago

19 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

10. Practitioner's Perspective - Managing Complex Cases of SIBO, Histamine, Oxalates & Mould

In this episode of the Histamine Well Podcast, Joanne is joined by Naturopath Mariela Gebhardt from Austria to discuss a fascinating and complex case. Initially thought to be related to SIBO, Mariela shares how, despite seeing early improvement in her patient's gut health, she remained in a heightened anxious state and developed an unusual symptom: toe pain. Mariela identified this as an oxalate issue, which was later confirmed through Organic Acids testing. This discovery prompted Mariela to...

2 months ago

37 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

9. Health Implications of Low Homocysteine – A Clinical Perspective

In this episode of the Histamine Well Podcast, host Joanne delves into the often-overlooked topic of low homocysteine levels. Joanne explains that while high homocysteine is commonly flagged for its cardiovascular risks, low homocysteine is seldom discussed despite its significant implications for health. She explores how low homocysteine can indicate sulfur depletion, often linked to issues such as oxalate toxicity and mold illness. The episode covers the methylation proces...

2 months ago

28 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

8. Insights Into Over & Under Methylation with Scientist James Bradshaw

In this episode of the Histamine Well, Joanne is joined by scientist James Bradshaw to discuss the complexities of methylation and its critical role in genetics, mood, and overall health. James shares his extensive background in biochemistry and cellular biology and introduces Mood Sense, the first saliva test for assessing methylation-related mood disruptions. They explore the essentials of methylation, its impact on neurotransmitter production, and the difference between over an...

2 months ago

1 hour 11 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

7. MTHFR, Methylation, Folic Acid & Folate Testing - A Clinical Perspective

In this episode of The Histamine Well Podcast, Joanne dives deep into the topic of MTHFR, an enzyme crucial for the process of methylation. Joanne explains the significance of methylation in various biochemical and genetic processes such as detoxification, neurotransmitter regulation, and genetic expression. The episode also addresses why methylfolate is essential, discusses common causes of methylfolate deficiency, and highlights why folic acid can be problematic for everyone. Joanne provid...

3 months ago

21 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

6. Understanding Multiple Food Intolerances: Histamine, Oxalates, Sulfur and More!

In this episode of The Histamine Well, Joanne breaks down the complexities of multiple food intolerances. She explains how SIBO and oxalates can drive up histamine, leading to oxalate, histamine, and FODMAP intolerances. Oxalates also deplete sulfur. This can cause an overgrowth of sulfur-producing bacteria in the gut, triggering sulfur intolerance. A lack of sulfur can also contribute to salicylate intolerance. Joanne explores the link between nervous system dysfunction and food intoleran...

3 months ago

18 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

5. Practitioner's Perspective- Managing SIBO and Hormonal Imbalances Without Testing: A Practical Approach

In this episode of the Histamine Well Podcast, Joanne is joined by naturopath Bridget Greenall to discuss Small Intestinal Bacterial Overgrowth (SIBO), particularly focusing on how to diagnose and treat it without testing. They explore the intertwined issues of SIBO, inflammation, and blood sugar dysregulation and their impact on hormonal health, including PMS and hot flushes. The conversation provides practical insights for practitioners, students, and patients on managing SIBO, ...

3 months ago

34 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

4. Balancing Oestrogen & Histamine: What Every Woman Should Know

In this episode of the Histamine Well podcast, Joanne delves into the intricate relationship between histamine and oestrogen. She explores how histamine can stimulate excess oestrogen production and vice versa, leading to a range of symptoms such as migraines, dizziness, anxiety, and digestive issues. Joanne discusses the impact of factors like methylation, gut health, and enzyme functionality on this dynamic. She provides practical advice on managing these issues, including dietary ad...

3 months ago

25 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

3. Are Oxalates Causing Your Histamine Intolerance and Lowering Homocysteine? | Featuring Melanie Peers

In this episode of the Histamine Well podcast, Joanne is joined by her colleague, Melanie Peers, an expert in oxalate issues. Together they explore the complex world of oxalates, their profound impact on histamine intolerance, methylation pathways, and overall health. They discuss how oxalates drive chronic inflammation, deplete sulfur levels, and disrupt both the methylation and transsulfuration pathways, causing low homocysteine levels. The discussion also covers the extensive sympt...

4 months ago

1 hour 18 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

2. Main Causes of Histamine Intolerance: What's Behind The Symptoms

High histamine levels are often a signal of deeper imbalances, and in this episode of The Histamine Well, we’re uncovering the hidden root causes that could be driving your symptoms. From SIBO and gluten intolerance to leaky gut and methylation issues, we’ll explore why histamine intolerance is rarely just about food and how addressing the underlying factors can lead to real, lasting solutions. Whether you’re managing your own health, supporting others on their journey as practitioner, ...

4 months ago

1 hour 7 minutes

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

1. Understanding Histamine: How it Works and What Happens When it's Too High

In the inaugural episode of the Histamine Well Podcast, Joanne, introduces the nuanced topic of histamine intolerance. Designed for both health practitioners and patients, the episode breaks down the science behind histamine, its role in the body, the widespread issue of chronic inflammation driving up histamine levels, and the symptoms it causes such as skin issues, gastrointestinal problems, anxiety, migraines, insomnia and hormonal imbalances. Joanne emphasizes the need for a compre...

4 months ago

35 minutes