When your body begins to lose its ability to respond to insulin effectively, this condition is known as insulin resistance. It places extra pressure on the beta cells of the pancreas, which are responsible for keeping blood sugar levels between 70 to 140 mg/dL. In a healthy individual, even after consuming something sweet—for example, mango juice—blood sugar gets automatically controlled through the quick response of beta cells, which release extra insulin to restore normal glucose levels. However, frequent consumption of high-calorie, high-sugar, or fatty foods significantly increases the workload on these beta cells. Over time, this constant strain can impair their function, disrupt the body’s glucose regulation, and eventually lead to diabetes. Importantly, diabetes is not just a “sugar problem”—it is also a vascular disease. It damages both large and small blood vessels throughout the body: - Large vessel complications include heart attacks (coronary artery disease), strokes (cerebrovascular disease), and leg artery blockages (peripheral artery disease), which can lead to gangrene. - Small vessel complications affect the eyes (diabetic retinopathy), kidneys (diabetic nephropathy), and nerves (diabetic neuropathy), damaging delicate blood vessels of these target organs and impairing vital filtering mechanisms.   Thus, diabetes is a chronic, systemic condition that impacts the entire vascular system and requires a comprehensive approach for prevention and management. Expert- Dr Sunil Gupta Anchor- Purva Kulkarni Recorded on: 24/04/2025 Recorded at: Akashwani Nagpur