In this episode, we delve into the OCTIVUS trial, a landmark study comparing optical coherence tomography (OCT) and intravascular ultrasound (IVUS) guidance during percutaneous coronary intervention for complex coronary artery lesions. With over 2,000 patients enrolled across nine centers in South Korea, the trial assessed outcomes in challenging cases, including left main disease, bifurcations, and heavily calcified lesions. Tune in as we explore the trial's design, key findings, and its implications for interventional cardiology practice.