This document presents the 2025 ACC/AHA guideline for managing patients with acute coronary syndromes (ACS). It covers the entire spectrum of ACS management, from initial evaluation and treatment strategies to long-term secondary prevention, and addresses specific conditions like STEMI and NSTE-ACS. The guideline provides recommendations on medical therapies such as antiplatelet agents, anticoagulants, and lipid management, as well as procedural interventions like PCI and CABG. Special considerations are given to complications such as cardiogenic shock and electrical or mechanical issues. Furthermore, the document emphasizes the importance of patient education, cardiac rehabilitation, and tailored discharge planning to improve long-term outcomes. (**AI-Assisted Podcast)