This JACC State-of-the-Art Review article provides a comprehensive overview of transcatheter tricuspid valve replacement (TTVR) for treating severe tricuspid regurgitation. The paper examines patient selection criteria, procedural techniques, and post-procedure care, including management of complications like conduction disturbances and bleeding. It details various TTVR systems and their characteristics,  presents clinical evidence from studies and registries, and discusses diagnostic imaging and hemodynamic assessment. Finally, the article outlines future research directions in TTVR and related interventions.