Welcome to H5N1 Global Scan: Avian Flu Worldwide, a Quiet Please production. Today, we take you around the globe for a fast-paced, factual update on the worldwide spread and impact of H5N1 avian influenza as of November 2025.
Since 2020, H5N1 has affected every continent except Australia. The most severe impacts have hit North and South America, Europe, Africa, and Asia. South America saw mass die-offs of wild birds, sea lions, and elephant seals, with Argentina reporting over 70 percent mortality in Southern elephant seal pups and an estimated 600,000 wild birds lost since 2022—drastically disrupting coastal ecosystems, according to data summarized in Wikipedia’s 2020–2025 H5N1 outbreak review.
North America’s experience has been notable for “spillover” events, especially in the United States and Canada. USDA and CDC reports detail H5N1 outbreaks in poultry, wild birds, and for the first time, widespread infections of dairy cattle in the US, leading to egg and milk shortages. By mid-2025, the CDC reports approximately 70 human infections, usually mild but including the country’s first H5N1 death. Human cases are mostly linked to direct animal contact; however, research cited by CIDRAP and CDC notes asymptomatic cases, raising concerns about surveillance gaps.
In Europe, the European Centre for Disease Prevention and Control highlights predominance of H5N1 in wild birds, with fewer poultry farm outbreaks compared to past seasons. Countries like Germany and Hungary have culled hundreds of thousands of birds. Europe’s risk assessment remains that for the general public, infection risk is low, but it is higher for those working with animals.
Asia continues to grapple with both rural and urban outbreaks. Cambodia, China, and India have reported clusters of human cases, regularly tied to exposure to sick poultry. The Food and Agriculture Organization’s April 2024 review highlighted genetic reassortment in Southeast Asia, signaling the virus’s potential to adapt and spreading across species barriers, raising flags for pandemic preparedness, as emphasized in a Nature article from October 2025.
Africa has recorded fewer human cases, but outbreaks in poultry and wild bird populations have led to trade bans and culling measures in major poultry-exporting countries. The FAO’s September 2025 global update tracks over 300 HPAI outbreaks/events globally since late August alone, underscoring persistent cross-border animal health challenges.
International response has centered around coordination and transparency. The World Health Organization and FAO have repeatedly called for enhanced surveillance, with WHO cautioning that no sustained human-to-human transmission has occurred, but the virus’s ability to infect mammals and reassort genetically requires vigilance.
Vaccine development is making progress, with several candidate vaccines for poultry and humans in late-stage trials. The United States and Europe are prioritizing stockpiling and rapid-response agreements, while China and India focus on local production for at-risk poultry sectors.
National containment approaches vary: the US and many European nations use mass culling, trade restrictions, and enhanced worker surveillance. Southeast Asian responses emphasize community engagement and compensation for farmers. The global consensus is strong: aggressive containment, broad-based scientific cooperation, and nimble supply chains are crucial.
Thank you for tuning in to H5N1 Global Scan: Avian Flu Worldwide. For more insights, join us next week. This has been a Quiet Please production—visit Quiet Please dot AI for more.
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