Join Drs. Lauren Rosenfeld and Dr. Arman Hussain cut through the confusion surrounding high sensitivity troponin (hs-Tn) in the Emergency Department. They break down what this cardiac injury marker actually measures, why the new assays allow for faster ACS screening (often in 1–2 hours) at the cost of more "false positives," and the practical application of 0/1h and 0/2h algorithms. They also dive into key pitfalls, including why cutoffs vary between hospitals, how to approach special populations like those with CKD.

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This production is done in partnership with Urgent Matters. Since 2002 Urgent matters has served as a premier dissemination vehicle for strategies on emergency department patient flow and quality.If you want to work with us to produce an episode or have any suggestions please reach out at gwemblog@gmail.com or aloganathan@mfa.gwu.edu.And finally to stay up to date on this podcast and our related efforts subscribe to our newsletter at https://urgentmatters.smhs.gwu.edu/.

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1. Stark M, Sharma S. Troponin. PubMed. Published 2023. https://www.ncbi.nlm.nih.gov/books/NBK507805/
2. Patibandla S, Alsayouri K. Cardiac enzymes. PubMed. Published November 17, 2023. https://www.ncbi.nlm.nih.gov/books/NBK545216/
3. Ming-yu Anthony Chuang, Gnanamanickam E, Karnon J, et al. Cost effectiveness of a 1-hour high-sensitivity troponin-T protocol: An analysis of the RAPID-TnT trial. IJC Heart & Vasculature. 2022;38:100933-100933. doi:https://doi.org/10.1016/j.ijcha.2021.100933
4. Information NC for B, Pike USNL of M 8600 R, MD B, Usa 20894. BUDGET IMPACT ANALYSIS. Canadian Agency for Drugs and Technologies in Health; 2013. https://www.ncbi.nlm.nih.gov/books/NBK168944/
5. Huggins C, Saltarelli N, Swoboda TK, et al. Kinetic changes in high-sensitivity cardiac troponin for risk stratification of emergency department chest pain patients. The American Journal of Emergency Medicine. 2025;93:176-181. doi:https://doi.org/10.1016/j.ajem.2025.04.010
6. Raber I, McCarthy CP, Januzzi JL. A Test in Context: Interpretation of High-Sensitivity Cardiac Troponin Assays in Different Clinical Settings. Journal of the American College of Cardiology. 2021;77(10):1357-1367. doi:https://doi.org/10.1016/j.jacc.2021.01.011
7. McEvoy JW, Tang O, Wang D, et al. Myocardial Injury Thresholds for 4 High-Sensitivity Troponin Assays in U.S. Adults. Journal of the American College of Cardiology. 2023;81(20):2028-2039. doi:https://doi.org/10.1016/j.jacc.2023.03.403
8. Byrne RA, Rossello X, Coughlan JJ, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. European Heart Journal. 2023;44(38). doi:https://doi.org/10.1093/eurheartj/ehad191
9. Kuster N, Monnier K, Baptista G, et al. Estimation of age- and comorbidities-adjusted percentiles of high-sensitivity cardiac troponin T levels in the elderly. Clinical chemistry and laboratory medicine. 2015;53(5). doi:https://doi.org/10.1515/cclm-2014-0121
10. Boeddinghaus J, Nestelberger T, Twerenbold R, et al. Impact of age on the performance of the ESC 0/1h-algorithms for early diagnosis of myocardial infarction. European Heart Journal. 2018;39(42):3780-3794. doi:https://doi.org/10.1093/eurheartj/ehy514
11. Kraus D, von Jeinsen B, Tzikas S, et al. Cardiac Troponins for the Diagnosis of Acute Myocardial Infarction in Chronic Kidney Disease. Journal of the American Heart Association. 2018;7(19). doi:https://doi.org/10.1161/jaha.117.008032