Several studies explore the relationship between moderate wine consumption and cancer risk, challenging the conventional view that all alcohol is carcinogenic. A large meta-analysis suggests moderate wine intake, particularly red wine, may not increase cancer risk and might even reduce it for certain cancers due to its unique bioactive compounds like resveratrol. Other research supports beneficial effects of moderate red wine consumption on various health outcomes, including mortality and dementia. We also discuss the Dietary Guildelines for Americans (DGA) 2025 on the health impacts of alcohol and the potential biases in the included studies. The overall consensus indicates the need for a nuanced approach, acknowledging both potential benefits and risks depending on consumption levels and individual factors.