In the final episode of our Loneliness and Well-being Series, Dr. Julianne Holt-Lunstad discusses the impact of social connections on health and mortality. She highlights the growing concern about loneliness and social isolation, emphasizing the need for interdisciplinary collaboration and effective policies to address these issues. Dr. Holt-Lunstad also discusses her involvement with organizations like the US Foundation for Social Connection and global initiatives aimed at bringing together researchers, policymakers, and community leaders to tackle loneliness and promote social connection worldwide. Throughout the episode, she underscores the importance of social ties for individual well-being and community resilience, particularly during crises. The conversation encourages collective efforts to advance solutions that enhance social connections and overall societal well-being.