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From First Principles
Lester Nare and Krishna Choudhary
14 episodes
5 days ago
We break down the week’s biggest science headlines from first principles—because understanding the world shouldn’t require a PhD.
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Science
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All content for From First Principles is the property of Lester Nare and Krishna Choudhary and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
We break down the week’s biggest science headlines from first principles—because understanding the world shouldn’t require a PhD.
Show more...
Science
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FFP EP. 5 | Hacking The Human Brain, Unlocking Our DNA, Unbreakable Diamonds & The Quantum Magician
From First Principles
2 hours 9 minutes 59 seconds
2 months ago
FFP EP. 5 | Hacking The Human Brain, Unlocking Our DNA, Unbreakable Diamonds & The Quantum Magician

This week we break down four big stories—no PhD required.

Reading “inner speech”: Invasive brain–computer interfaces record neurons in motor cortex and decode attempted vs. inner speech into words. Results from Stanford even generalize to simple symbols and numbers. Cool science, huge privacy questions, and a proposed “brain password” to keep users in control.
What makes us human: UC San Diego highlights human accelerated regions (HARs)—genomic control switches (promoters/enhancers) that tune when and where genes are used. We revisit classic HAR examples and a new result connecting a specific HAR to brain development.
Diamonds get an upgrade: Scientists at HPSTAR (Beijing) grow stronger lab diamonds with clear industrial upside—from cutting tools to power electronics—and potential to reduce harmful mining incentives.
International Year of Quantum (2025): A fast retrospective on 100 years of quantum mechanics and how today’s quantum tech is reshaping computing, sensing, and materials.

Hosts: Lester Nare & Dr. Krishna Choudhary
Show: From First Principles Podcast

From First Principles
We break down the week’s biggest science headlines from first principles—because understanding the world shouldn’t require a PhD.