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From First Principles
Lester Nare and Krishna Choudhary
14 episodes
5 days ago
We break down the week’s biggest science headlines from first principles—because understanding the world shouldn’t require a PhD.
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Science
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All content for From First Principles is the property of Lester Nare and Krishna Choudhary and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
We break down the week’s biggest science headlines from first principles—because understanding the world shouldn’t require a PhD.
Show more...
Science
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FFP EP. 4 | 3rd Interstellar Visitor, Rubin’s Sky Camera, AI CRISPR Boost & T. rex Blood Vessels
From First Principles
1 hour 22 minutes 8 seconds
2 months ago
FFP EP. 4 | 3rd Interstellar Visitor, Rubin’s Sky Camera, AI CRISPR Boost & T. rex Blood Vessels

Interstellar visitor #3 is here. We unpack 3I ATLAS (why it’s moving so fast, why we finally saw a tail, and how Hubble/JWST—and maybe even Juno—could nail down its makeup). Then we dive into the Vera Rubin Observatory, the 32-gigapixel camera that will turn the entire sky into a time-lapse movie and supercharge discovery. Next: AI just boosted CRISPR by predicting and guiding DNA repair (Pythia), making edits cleaner—especially in non-dividing neurons. And we close with a crossover of dinos + particle physics: preserved T. rex blood vessels revealed by a synchrotron. Mystery Box: the viral “Black aliens” meme.


From First Principles
We break down the week’s biggest science headlines from first principles—because understanding the world shouldn’t require a PhD.