This lecture explores basic definitions of Occupational Science and how occupational science enhances our understanding of the construct of "Occupation" by exploring its influence on various formal definitions of occupation that have evolved along with developments in Occupational Science over time. This video also acknowledges limitations in defining occupation accurately across diverse cultural contexts internationally. This video is meant to inspire curiosity rather than conclusive clarity of the definition of Occupational Science and the phenomena and threshold concept of Occupation and what it means to explore it scientifically with accuracy and holism and how it can be leveraged therapeutically and constructively in our practice settings.