In this series, Thomas Dayspring, M.D., one of the world's most recognised experts in lipidology, shares his breadth of knowledge on heart disease prevention.   Part 4 covers strategies to maximise longevity and reduce your risk of heart disease.  

00:00  Intro  

01:34 Target ApoB & Temporality 

04:07 Ketogenic diet 

08:12 Lipoprotein(a) & aortic stenosis 

14:44 Oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) 

16:51 Getting tested 

18:25 Are statins “natural”? 

20:55 Combination therapies 

23:31 Triglycerides 

26:18 Non-HDL cholesterol 

27:06 Why is there no guideline for triglyceride therapy ? 

27:51 Risk factors for Alzheimer's disease 

34:45 Protocol to treat elevated ApoB 

41:22 Tom's favourite books & textbooks 

45:13 Meaning of life 

50:31 Tom's ApoB 

53:18 Tom’s intermittent fasting 

57:06 Tom's daily routine 

1:00:14 Outro  

Here are the key metrics to shoot for in your lipid panel following the heart disease masterclass with Dr Thomas Dayspring.   

Gold standard measure for heart disease risk  

ApoB less than 80 mg/dl,  

For people at high risk, less than 50 mg/dl   

If the ApoB test is not available, there a couple of metrics related to ApoB that you can use:  

LDL-C less than 70-100 mg/dl,  

For people at high risk, less than 55 mg/dl 

OR 

non-HDL cholesterol  less than 130 mg/dl  

For people at high risk less than 70 mg/dl   

Are you at risk of the lp(a) particle. 

You only need to perform this once in your life.  You are at risk if you reading is more than 30 mg/dL  

Oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) could be a useful secondary test for those with high lp(a) to measure additional risk  

You can also take phytosterol test (sitosterol, and campesterol) to check if you are hyper absorber of cholesterol. This is better than a genetic test   

Triglycerides.  

There is no guideline for triglyceride therapy, but a good value to shoot for could be:  

less than 80-100 mg/dl  

The human apolipoprotein E4 isoform (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD)  

Give Tom a follow on Twitter: https://twitter.com/Drlipid  

Other appearances from Tom: 

Drive Podcast https://www.youtube.com/watch?v=PllTHYgWpuwWellness: Fact vs. Fiction https://podcasts.apple.com/us/podcast/a-masterclass-in-cholesterol-and-lipid-lowering/id1447250475?i=1000581954971Nutrition Made Simple lp(a): https://www.youtube.com/watch?v=-WRRyG8il4gDietary cholesterol: https://www.youtube.com/watch?v=GkWMDnTyxfoCoronary Calcium Score (CAC): https://www.youtube.com/watch?v=gxIeRUbHauw Narrative glossary on lipids provided by Tom: https://peterattiamd.com/glossary-lipids/