In this episode, Robert J. Noecker, MD, reviews the role of preservatives, particularly benzalkonium chloride (BAK), in ophthalmic medications. While BAK effectively prevents bacterial growth, its inherent toxicity poses challenges with prolonged use, leading to symptoms associated with ocular surface diseases. Dr. Noecker emphasizes the importance of exploring alternatives like preservative-free formulations or less toxic oxidizing preservatives, which should ensure effective glaucoma treatment without compromising ocular health. This activity is supported by an independent medical education grant from Théa Pharma.