In this episode of Exploration Science, Drs. Gemma Mudd and Kevin McDonnell of Bicycle Therapeutics discuss the Bicycle peptide platform and dive into some of the properties of bicycles that enable the generation of molecules with high affinity, selectivity, and tunable pharmacology.

Links:

https://www.bicycletherapeutics.com/

Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides DOI: 10.1021/acs.bioconjchem.2c00288

Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors

DOI: 10.1158/0008-5472.CAN-18-0238

Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology

DOI: 10.1021/acs.jmedchem.2c00505