Welcome to the Evidence-Based Hair Podcast, hosted by dermatologist and hair loss specialist Dr. Jeff Donovan. As the director of the Donovan Hair Academy, Dr. Donovan is dedicated to educating the public and training practitioners in the complex field of hair loss. In this episode, Dr. Donovan delves into a fascinating study from JAMA Dermatology that examines the effects of low-dose metformin on Central Centrifugal Cicatricial Alopecia (CCCA). The study reveals intriguing changes in gene expression that could offer new insights into treating this underdiagnosed condition, primarily affecting black women. Despite the study's small size and retrospective nature, the findings highlight metformin's potential role in modifying pathways related to scarring alopecia and hair growth. Dr. Donovan emphasizes the need for further research to understand metformin's efficacy and optimal dosing for CCCA patients. Join us next week as Dr. Donovan discusses the use of metformin cream in CCCA, continuing the exploration of innovative treatments in hair loss management. Stay informed and empowered to engage in meaningful discussions with hair loss practitioners.     STUDY REFERENCED IN THIS EPISODE Aaron Bao et al. Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia. JAMA Dermatol . 2024 Sep 4:e243062. doi: 10.1001/jamadermatol.2024.3062. Online ahead of print.