In part 2 of our Nuclear Energy Series, our panel delves into the critical role of supply chain management, data orchestration, and digital twins in shaping the future of nuclear power. The conversation highlights how these innovations are not only enhancing the safety and reliability of nuclear operations but also unlocking new possibilities for optimization and predictive maintenance.  Key highlights of the discussion include: Digitalization and data orchestration are crucial to enable a "nuclear renaissance" Digital twins and advanced analytics (AI, ML, physics-informed models) enable: Simulation of "what-if" scenarios to predict and prevent failures Informed, real-time predictions of asset degradation and maintenance needs New nuclear reactor designs are prioritizing maintainability and serviceability to address historical challenges Reduced order models and edge computing are empowering near real-time simulation and decision-making for operators Collaboration between nuclear operators, regulators, and technology providers is crucial to accelerate the adoption of these transformative digital capabilities