The End of Human Evolution As We Know It | Orchid’s Noor Siddiqui

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Endgame with Amanda Cassatt

Serotonin

21 episodes

4 days ago

The world is changing at an accelerating pace—Endgame is here to make sense of it. Hosted by Amanda Cassatt, founder of Serotonin, this podcast brings you conversations with the visionaries driving breakthrough technologies and shaping the future. Join Amanda as she unpacks the trends, innovations, and paradigm shifts defining our time. Where is this all going? Let’s figure it out together. Subscribe now on Apple Podcasts, Spotify, YouTube, and wherever you listen.

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The End of Human Evolution As We Know It | Orchid’s Noor Siddiqui

Endgame with Amanda Cassatt

54 minutes 12 seconds

2 months ago

The End of Human Evolution As We Know It | Orchid’s Noor Siddiqui

What if you could choose your child before they’re born?

Noor Siddiqui, founder of Orchid, joins Amanda Cassatt to explore one of the most profound frontiers in biotech: genetically screening and selecting embryos during IVF. At the intersection of science, ethics, and the human desire for legacy, this conversation asks how far we’re willing to go to optimize health, reduce suffering, and rethink what it means to become a parent.

They examine the promises and perils of “super babies,” a futuristic term quietly approaching reality. Once reserved for preventing rare genetic diseases, embryo testing is now exploring polygenic scoring, offering parents insight not only into potential health outcomes but also into cognitive traits such as IQ. With that insight comes questions about eugenics, equity, and where the line lies between informed choice and engineered outcomes.

Noor shares how the burden of genetic disease shapes families and why she believes informed embryo selection can empower rather than control. Amanda and Noor also discuss the fertility crisis, the economic and cultural shifts reshaping family planning, and what it would take to build a world where having a child doesn’t demand superhuman effort or superhuman genes.

TIMESTAMPS:

00:00 Introduction to Orchid and IVF Technology

02:57 Understanding Genetic Testing in Embryos

06:08 The Concept of 'Super Babies' and Genetic Blessings

09:03 Selection Pressure in Embryo Choices

12:02 The Burden of Genetic Diseases

14:43 Ethical Considerations in Genetic Selection

17:49 The Future of Reproductive Technology

20:49 Enhancements vs. Remediation in Genetic Technology

23:36 The Role of Cost in IVF Accessibility

26:32 The Future of Genetic Editing and CRISPR

29:40 Conclusion and Future Outlook

40:57 The Future of Reproductive Technology

44:21 The Global Fertility Crisis

48:40 Cultural Shifts in Parenthood

51:24 The Purpose of Life and Parenthood

55:53 Nature vs. Nurture in Child Development

59:47 Personal Aspirations and Family Planning

01:02:09 The Ethics of Genetic Selection

01:08:54 Existential Questions and Identity