In a follow-up from the live in-conversation of Einstein-A-Go-Go two years ago, this guest-packed show revisits the topic of endometriosis. Shane is joined in the studio by Dr Susi and Dr Lauren to interview two surgeons and two scientists. Dr Kate Tyson is a gynaecologist and advanced laparoscopic surgeon who directs the Julia Argyrou Endometriosis Centre at Epworth. Dr Samantha Mooney is an obstetrician and gynaecologist at the Mercy Hospital for Women, and also the University of Melbourne as part of the End-IT Endometriosis group. Kate and Samantha talk about the complex nature of endometriosis as a condition, and the use of different types of imaging technology to guide surgical choices. Also joining the show are Dr Fiona Cousins and Dr Harriet Fitzgerald, both research fellows at the Hudson Institute of Medical Research with Monash University. Harriet shares her research about the cause of endometriosis, and Fiona is conducting research on immunotherapy drug treatments for endometriosis to try and reduce or avoid surgery. Susi and Lauren also share science news about the recent approval of a non-opioid pain relief drug by the American Food and Drug Administration, and the science behind why we all want to desperately scratch that itch.