This original, unedited manuscript addresses the use of microbial biological control agents (MBCAs) as a sustainable alternative to synthetic insecticides, particularly in the face of the global increase in pests driven by climate change. The text highlights Canada’s leadership in successfully integrating MBCAs into agriculture, attributable to supportive policies, research funding, and adaptive regulatory frameworks. While MBCAs offer advantages such as high specificity and reduced environmental impact, they also face challenges, including slower action and variable consistency. These limitations underscore the need for innovations in application methods and more coherent global regulation. The perspective proposes a strategic framework that emphasizes regulatory harmonization, increased government support, global standardization of data, and public–private collaboration to promote the widespread adoption of MBCAs, thereby contributing to food security and the achievement of sustainable development goals.