This study examines how rising temperatures associated with climate change impact the plant immune system. The authors demonstrate that elevated temperatures suppress systemic acquired resistance (SAR), a broad-spectrum defence mechanism against pathogens. This suppression is directly tied to reduced biosynthesis of N-hydroxypipecolic acid (NHP), a key SAR signaling molecule, in Arabidopsis and other plant species. The study further explains that this thermal vulnerability is controlled by the regulation of the transcription factors CBP60g and SARD1, providing new avenues for developing climate-resilient crops.https://doi.org/10.1111/tpj.70374