The cephalosporin antibiotics are a confusing class of medications. We talk about them in "generations" like a pharmacologic family tree. And while there is a general rule regarding which bugs are covered by the different generations, the exceptions to that rule are numerous and just as important as the rule itself. In this 2-part episode, we'll unpack the cephalosporins a bit. We'll explain what it means for one agent to be "better" than another at treating a particular bacteria and why the 4th and 5th generations only have one drug each. In the end, we wont be infectious disease experts but you also wont have to call them the "Ceph-a-somethings" ever again.