Cystic Fibrosis (CF): Metabolic Adaptations of Pseudomonas Aeruginosa

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Dr@Home

Dr Sean Kassen, PhD DIC

18 episodes

4 days ago

Join in on my journey of life as it happens as a biomedical science, research and education enthusiast. I am passionate about proactive health management; mentoring; coaching; and believe that knowledge is power and we need to seek out data and information that enhances our lives holistically, i.e. body, mind, and soul to find true balance across these elements for a healthy, prosperous, and fulfilling life.

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Cystic Fibrosis (CF): Metabolic Adaptations of Pseudomonas Aeruginosa_Part 2

Dr@Home

25 minutes 33 seconds

9 months ago

Cystic Fibrosis (CF): Metabolic Adaptations of Pseudomonas Aeruginosa_Part 2

Cystic fibrosis (CF) is a complex genetic disorder with significant implications for those affected. While there is currently no cure, advancements in our understanding of the disease, its genetic underpinnings, and the development of targeted therapies are improving both life expectancy and quality of life for those affected. Yet, many challenges remain especially on the metabolic adaptations of Pseudomonas aeruginosa (P. aeruginosa) during chronic infections in the lungs of individuals with Cystic Fibrosis (CF). These adaptations are not simply a consequence of the environment, but an active process driven by specific mutations and metabolic shifts that impact virulence, immune evasion and interactions within the CF lung. A key finding is that mutations in the PDHc, causing shifts in pyruvate metabolism, play a central role in driving this adaption. Further research into these metabolic changes is essential for developing more effective treatment strategies for CF-related infections. The use of advanced metabolomics, proteomics, and in vitro models is essential to understanding this dynamic process.

A few sources: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002781⁠; https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.617784/full ⁠⁠; ⁠https://www.sciencedirect.com/science/article/pii/S0966842X16000214⁠; https://pmc.ncbi.nlm.nih.gov/articles/PMC6835255/

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