Chris Magryta, M.D., commonly known as Dr. M, has been studying the effects of human lifestyle decisions on disease risk and longevity for decades. He has decided to take this information and specifically hone down the focus to mothers and their children with a desire to improve longevity and health outcomes. How do we set up a mother for ideal health and prepare a child for a great start at life? How do we then provide the best environment for a child to succeed mentally and physically throughout childhood? These are many other questions will be addressed in the Women and Children podcast. So sit back, download a few podcasts, and let us learn together today!
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Chris Magryta, M.D., commonly known as Dr. M, has been studying the effects of human lifestyle decisions on disease risk and longevity for decades. He has decided to take this information and specifically hone down the focus to mothers and their children with a desire to improve longevity and health outcomes. How do we set up a mother for ideal health and prepare a child for a great start at life? How do we then provide the best environment for a child to succeed mentally and physically throughout childhood? These are many other questions will be addressed in the Women and Children podcast. So sit back, download a few podcasts, and let us learn together today!
Inflammaging from a Population View
In a landmark study published in Nature Aging on July 7, 2025, researchers challenge a cornerstone of modern gerontology by showing that inflammaging, chronic, age-associated low-grade inflammation, is not universal across all human populations. The abstract states the following: "Inflammaging, an age-associated increase in chronic inflammation, is considered a hallmark of aging. However, there is no consensus approach to measuring inflammaging based on circulating cytokines. Here we assessed whether an inflammaging axis detected in the Italian InCHIANTI dataset comprising 19 cytokines could be generalized to a different industrialized population (Singapore Longitudinal Aging Study) or to two indigenous, nonindustrialized populations: the Tsimane from the Bolivian Amazon and the Orang Asli from Peninsular Malaysia.
We assessed cytokine axis structure similarity and whether the inflammaging axis replicating the InCHIANTI result increased with age or was associated with health outcomes. The Singapore Longitudinal Aging Study was similar to InCHIANTI except for IL-6 and IL-1RA. The Tsimane and Orang Asli showed markedly different axis structures with little to no association with age and no association with age-related diseases. Inflammaging, as measured in this manner in these cohorts, thus appears to be largely a byproduct of industrialized lifestyles, with major variation across environments and populations." (Franck et. al. 2025)
The research team analyzed 19 cytokines in over 2,800 individuals from four diverse populations: two industrialized cohorts: Italy's InCHIANTI and the Singapore Longitudinal Aging Study (SLAS); two non-industrialized, Indigenous groups: the Tsimane of the Bolivian Amazon and the Orang Asli of Peninsular Malaysia.
In Italy and Singapore, the industrialized regions noted classic inflammaging signatures with inflammatory markers like IL‑6, TNF-α, and CRP increased with age, and correlated strongly with age-related chronic diseases such as cardiovascular and kidney disease..... and more on inflammaging...
Dr. M
Dr. M's Women and Children First Podcast
Chris Magryta, M.D., commonly known as Dr. M, has been studying the effects of human lifestyle decisions on disease risk and longevity for decades. He has decided to take this information and specifically hone down the focus to mothers and their children with a desire to improve longevity and health outcomes. How do we set up a mother for ideal health and prepare a child for a great start at life? How do we then provide the best environment for a child to succeed mentally and physically throughout childhood? These are many other questions will be addressed in the Women and Children podcast. So sit back, download a few podcasts, and let us learn together today!
