In this deep dive, we break down the journey of the PIM Kinase target. We explore the complex PIM1 molecular mechanism, examine why first-generation pan-PIM inhibitors like AZD-1208 faced safety issues and a lack of monotherapy efficacy, and reveal the final clinical verdict of the Terminated and Completed Phase 1 studies.

📖 Video Chapters:

0:00 - Intro

1:05 - Biobanks Associations for PIM1

22:18 - PIM1 Gene

39:00 - PIM1 Protein

52:52 - PIM1 Known Drugs and Clinical Trials