The Endo-crimes of Lupus: Unravelling the Gender Disparity

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Disease Vs

Dr Daniel Andrews, Monash University

11 episodes

2 days ago

Disease Vs is all about diving into the biggest battles in modern science — from cancer to antibiotic resistance — and uncover how breakthroughs in biomedical research are reshaping how we treat diseases and deal with global heath challenges!

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The Endo-crimes of Lupus: Unravelling the Gender Disparity

Disease Vs

20 minutes

5 months ago

The Endo-crimes of Lupus: Unravelling the Gender Disparity

Selina, Helya & Thiri take a look into the complex world of autoimmunity by taking a look at Lupus. They shed light on why 9 out of 10 people with lupus are female and how hormones can play a key role in the onset of lupus. Tune in to find out more!

References:

[1] Ding, Z. (2025). Week 9: B Cells and Molecular Mechanisms of Disease, Lecture 32; accessed on 01/05/2025.

[2] Maidhof, W. and Hilas, O. (2012). Lupus: an overview of the disease and management options. P&T, 37(4), p.240. [3] Guéry, J.C. (2019). Why is systemic lupus erythematosus more common in women? J. Bone Spine, 86(3):297-9.

4] Sachdeva, R., Pal, R. (2022). The influence of reproductive hormones on systemic lupus erythematosus. Explor. Immunol., 2(3):351-62

[5] Graham, J.H., Yoachim, S.D., and Gould, K.A. (2020). Estrogen receptor alpha signaling is responsible for the female sex bias in the loss of tolerance and immune cell activation induced by the lupus susceptibility locus Sle1b. Front. Immunol., 11:582214.

[6] Dao, K.H., and Bermas, B.L. (2022). Systemic lupus erythematosus management in pregnancy. Int. J. women's health, 15:199-211.

[7] Hu, C., Liu, H., Pang, B., Wu, H., Lin, X., Zhen, Y., and Yi, H. (2021). Supraphysiological estradiol promotes human T follicular helper cell differentiation and favours humoural immunity during in vitro fertilization. J. Cell. Mol. Med., 25(14):6524-34.

[8] Delgado, B.J., and Lopez-Ojeda, W. (2019). Estrogen. [9] Harding, A.T., and Heaton, N.S. (2022). The impact of estrogens and their receptors on immunity and inflammation during infection. Cancers, 14(4), p.909.

[10] Chen, P., Li, B., and Ou-Yang, L. (2022). Role of estrogen receptors in health and disease. Front. Endocrinol., 13, p.839005.

[11] Abdolahpour, S., Abdolahi, N., Aghaei, M., Azadeh, H., and Farazmandfar, T. (2025). The Effect of Estradiol and Testosterone Levels Alone or in Combination with Their Receptors in Predicting the Severity of Systemic Lupus Erythematosus: A Cohort Study. Iran. J. Med. Sci., 50(2), p.69.

[12] Parks, C.G., Santos, A.D.S.E., Barbhaiya, M., and Costenbader, K.H. (2017). Understanding the role of environmental factors in the development of systemic lupus erythematosus. Best Pract. Res.: Clin. Rheumatol., 31(3), pp.306-320.

[13] Buie, J., McMillan, E., Kirby, J., Cardenas, L.A., Eftekhari, S., Feldman, C.H., Gawuga, C., Knight, A.M., Lim, S.S., McCalla, S., and McClamb, D. (2023). Disparities in lupus and the role of social determinants of health: current state of knowledge and directions for future research. ACR open rheumatology, 5(9), pp.454-464.

[14] Guffroy, A., Jacquel, L., Guffroy, B., and Martin, T. (2024). CAR-T cells for treating systemic lupus erythematosus: A promising emerging therapy. J. Bone Spine, 91(5), p.105702.

Links to Audio Clips & Sound effects

[1] Introduction music: https://www.epidemicsound.com/track/9bms0Xvzb6/

[2] Paparazzi sounds: