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Disease Vs
Dr Daniel Andrews, Monash University
11 episodes
2 days ago
Disease Vs is all about diving into the biggest battles in modern science — from cancer to antibiotic resistance — and uncover how breakthroughs in biomedical research are reshaping how we treat diseases and deal with global heath challenges!
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Science
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All content for Disease Vs is the property of Dr Daniel Andrews, Monash University and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
Disease Vs is all about diving into the biggest battles in modern science — from cancer to antibiotic resistance — and uncover how breakthroughs in biomedical research are reshaping how we treat diseases and deal with global heath challenges!
Show more...
Science
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No MS-ing Around: How monoclonal antibodies are revolutionising multiple sclerosis treatment
Disease Vs
19 minutes 56 seconds
5 months ago
No MS-ing Around: How monoclonal antibodies are revolutionising multiple sclerosis treatment

From incurable to manageable – science is rewriting the story of MS. Join Natalie, Prio, and Ethan as they explore how monoclonal antibodies are revolutionising treatment for multiple sclerosis.

References:

[1] MS Australia (2025). Key Facts & Figures About Multiple Sclerosis. Company website, accessed on 01/05/25. [2] Pisetsky, D.S. (2023). Pathogenesis of autoimmune disease. Nature, 19, 509–524. [3] van Langelaar, J., Rijvers, L., Smolders, J., and van Luijn, M.M. (2020). B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers. Front Immunol, 11, 760. [4] Korn, T. (2008). Pathophysiology of multiple sclerosis. J Neurol, 255, 2-6. [5] Huang, J.K., Fancy, S.P.J., Zhao, C., Rowitch D.J., ffrench-Constant, C., and Franklin R.J.M. (2011). Myelin Regeneration in Multiple Sclerosis: Targeting Endogenous Stem Cells. Neurotherapeutics, 8(4), 650–658.

[6] MS Trust (2022). Managing Relapses. Company website, accessed on 04/05/25.

[7] Ransohoff, R.M., Hafler, D.A., and Lucchinetti, C.F. (2015). Multiple sclerosis–a quiet revolution. Nat Rev Neurol, 11(3), 134–142.

[8] Cree, B.A.C., Oksenberg, J.R., and Hauser, S.L. (2022). Multiple sclerosis: two decades of progress. Lancet Neurol, 21(3), 211–214.

[9] Comi, G., and Radaelli, M. (2015). Oral corticosteroids for multiple sclerosis relapse. Lancet, 386(9997), 937-939.

[10] Tramacere, I., Giovane, C.D., Salanti, G., D'Amico, R., and Filippini, G. (2015). Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis. Cochrane Database Syst Rev, 1(1), CD011381.

[11] Rosenblum, M.D., Gratz I.K., Paw, J.S., and Abbas, A.K. (2012). Treating Human Autoimmunity: Current Practice and Future Prospects. Sci Transl Med, 4(125), 125sr1.

[12] Alejandra, W.P., Irene J.P.M., Antonio G.S.F., et al. (2023). Production of monoclonal antibodies for therapeutic purposes: A review. Int Immunopharmacol, 120, 110376.

[13] Mekala R.R., Nalluri, H.P., Reddy P.N., et al. (2024). Emerging trends and therapeutic applications of monoclonal antibodies. Gene, 925, 148607. [14] Polman, C.H., O’Connor, P.W., Havrdova, E., et al. (2006). A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis. N Engl J Med, 354(9), 899-910.

[15] Manouchehrinia, A., Larsson, H., Karim, M.E., Lycke, J., Olsson, T., and Kockum, I. (2023). Comparative effectiveness of natalizumab on cognition in multiple sclerosis: A cohort study. Mult Scler, 29(4-5), 628-636.

[16] Delbue, S., Comar, M., and Ferrante, P. (2016). Natalizumab treatment of multiple sclerosis: new insights. Immunotherapy, 9(2), 157-171.

[17] Chen, J., Diouf, I., Taylor, B.V., Kalincik, T., and van der Mei, I. (2022). Superior effects of natalizumab versus other DMTs on patient-reported outcomes in people with multiple sclerosis. J Neurol Neurosurg Psychiatry, 93(10), 1120-1127.

[18] USCF (2025). Stephen Hauser Wins Breakthrough Prize for Role in Redefining MS. University of California San Francisco. Company website, accessed on 29/4/2025.

[19] Hauser, S.L., Bar-Or, A., Cohen, J.A., et al. (2020). Ofatumumab versus Teriflunomide in Multiple Sclerosis. N Engl J Med, 383(6), 546-557.

Disease Vs
Disease Vs is all about diving into the biggest battles in modern science — from cancer to antibiotic resistance — and uncover how breakthroughs in biomedical research are reshaping how we treat diseases and deal with global heath challenges!